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Pharmacological inhibition of GIPR with anti-GIPR antibodies prevented BW gain in DIO mice and obese cynomolgus monkeys 33
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Losing 1020 pounds may take a few months, while 4070+ pounds typically requires long-term, consistent treatment
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Ethics statement The animal study was approved by Prof
Developed by Eli Lilly as a triple-receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, retatrutide achieved a mean body weight reduction of -24.2% at its highest dose over 48 weeks surpassing both semaglutide and tirzepatide in their respective pivotal trials
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