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The pancreas has two main functions: the first (exocrine) is to produce and secrete digestive enzymes to break down food so it can be absorbed and the second (endocrine) is to produce hormones like insulin and glucagon that regulate blood sugar levels

"Effect of long-term oral glutathione supplementation on gut microbiome of type 2 diabetic individuals." FEMS Microbiol Lett

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As a result, SGLT2 inhibitors are now recommended as first add-on (or even first-line, alongside metformin) when someone has established cardiovascular disease, heart failure, or chronic kidney disease: even if their HbA1c is at target

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