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Nature Reviews Endocrinology , 13(10), 577-591
Notably, while both carbohydrate and fat ingestions induce considerable increase in GIP secretion, plasma GLP-1 levels primarily surge after glucose-rich meals (56) [ Figure 1 Section A]
Although ZMC1 targets the p53 R175H mutant, it also affects several p53 R273H and p53 R248Q mutants that lack binding affinity between p53 and DNA
I remain open to evidence that any one of these peptides or NAD+ will eventually be shown to provide useful health outcome benefits
Unveiling the structural basis for the ligand specificities of this series of proteins will help us understand the evolution and discrimination of SL and KAR signals
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