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CAS: 42464-96-0, PubChem CID: 950107

Importantly, we see that the increase in mitochondrial mass is cancer-cell-specific (Extended Data Fig

As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization

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