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428 The early mechanistic models of MAPK pathway dynamics by Doug Lauffenburger quantified how negative feedback controls signal adaptation, and his concept of temporal collateral sensitivity provides a theoretical basis for adaptive therapy

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This suggests that our observed elevation in Gln levels and Gln/Glu ratio in adults with ASD might, at least in part, represent a compensatory adaptation within the glutamatergic system aimed at modulating its function