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DTT, TCEP, or beta-mercaptoethanol at high concentrations will cleave this bridge and inactivate the peptide

A lethal dose has not been established in animal models, and prolonged administration (over several weeks) showed no apparent adverse effects compared with controls

However, biochemists speculate that there may have been some concurrent advantage of this mutation that caused it to persist and spread in the human lineage

Hayot M, Michaud A, Koechlin C, Caron MA, LeBlanc P, Prefaut C, Maltais F

nutrition, detoxification, de-acidification, antibiotics, bacterial strains and thus the required conditions are almost never obtained