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We found similar cellular enrichment patterns in the validation dataset with positive enrichments of the CD4 and CD8 T lymphocytes, B cells, and negative enrichment of macrophages in end-stage COPD when compared to controls (Fig

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Pharmaceutical companies invest heavily in clinical trials to establish safety, efficacy, and optimal dosage, which is critical for regulatory approval and market success

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In the protective response of the testis to heat stress, HSF1 acts as an upstream transcriptional regulator, whereas members of the HSP70 family, particularly HSPA1 and HSPA2, serve as key protective factors in maintaining germ-cell proteostasis and preventing apoptosis

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Amary et al., 2011

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