Studies in cultures of mixed intestinal epithelial cells and in model enteroendocrine cells (e.g., STC-1 and GLUTag) have demonstrated the expression of the bile acid G protein-coupled receptor, TGR5, and the ability of bile acids to activate TGR5 and stimulate GLP-1 secretion (Kidd et al., 2012)
In this study, the more commonly used -Arbutin was selected for docking analysis (Fig
Just that one small subtle substitution, enhancing the molecular weight by 14 daltons, substantially increased the stability of the the peptide, says Paul Levine, a chemist at peptide company Insamo in California, US
Nat Clin Pract Endocrinol Metab 1:2231 Lee YH, Wang MY, Yu XX, Unger RH (2016) Glucagon is the key factor in the development of diabetes
In Saudi Arabia, the prevalence of tobacco use remains a significant public health concern