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Macrophage activation in hypoxic osteosarcoma cells H 2 O 2 is one of the main products of the catalytic reaction

These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

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Churin Y, Schilling S, Brner T (1999) A gene family encoding glutathione peroxidase homologues in Hordeum vulgare (barley)