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588,168 adults with type 2 diabetes: 139,546 started a GLP-1 drug 448,622 started an SGLT2 inhibitor Followed for up to 3 yearsAt 3 years, NAION was more frequent among people who started GLP-1 drugs: GLP-1 drugs: 39.1 cases per 10,000 persons SGLT2 inhibitors: 29.3 cases per 10,000 persons That works out to 6 to 10 extra cases per 10,000
Reduced glutathione (GSH) is the active antioxidant species that directly scavenges reactive oxygen species and free radicals, while oxidized glutathione (GSSG) is formed when two GSH molecules are linked via a disulfide bond after oxidation
Jun 132023;11(6)doi:10.3390/biomedicines11061701
Glucagon-like peptide-1 receptor agonist treatment does not reduce abuse-related effects of opioid drugs
If proven equally effective, they could dramatically expand adoption, especially among patients needle-averse or unwilling to self-inject
