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doi:10.1091/mbc.8.9.1699 Inoue, Y., Maeta, K., & Nomura, W

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In a three-month study with 58 hypertensive patients, taking the anti-hypertensive drug nifedipine (a calcium channel blocker), the plasma levels of vasoconstrictor molecule endothelin-1 were significantly lowered by 9% after one month and by 16% after three months in the group taking 100 mg Pycnogenol compared to the placebo group (20)