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glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long-term (52-week) extension of a 52-week randomised controlled trial
In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents
At that dose, 100%, 93%, and 83% of participants achieved weight reductions of at least 5%, 10%, and 15%, respectively, compared with 27%, 9%, and 2% on placebo
Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions
In conclusion, while the connection between Mounjaro and depression is still under investigation, being informed and vigilant about potential symptoms can empower users to manage their health proactively
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