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For structural studies, a Src-5Cys mutant (C185S, C238S, C245S, C277S, C400S) was generated
The first is chemical: whether the three species are inert toward one another in the vial and in solution, which is a question about redox activity, metal-ligand competition and oxidation, and which has an answer that depends on the specific formulation rather than on any published pharmacology
There are references to early-phase or investigator-initiated work in specific niches (such as inflammatory bowel conditions), but no robust, peer-reviewed, placebo-controlled human safety dataset has been widely published
A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig
Badawy AM, et al
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