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In studies with rodents, GLP-1 receptor activation resulted in a reduction in nicotine self-administration

When safety information does show up, it's often from accidental cases

Biomed Pharmacother 2021;140:111778.ArticlePubMed 58

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The combination of afamelanotide implant plus NB-UVB achieved 48.6% repigmentation at day 168, compared to 33.3% with NB-UVB monotherapy a statistically significant and clinically meaningful difference (Lim et al., 2015)