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Furthermore, TMAO-induced activation of the NLRP3 inflammasome, a proinflammatory protein complex, results in increased production of the proinflammatory cytokine IL-1 both in vitro and in vivo , which contributes to endothelial injury ( + -dependent protein deacetylase sirtuin3 (Sirt3) and subsequent inhibition of manganese superoxide dismutase 2 (SOD2) activation (Rogacev et al., 2012
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