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The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems
Unlike natural amylin, which has a very short half-life, cagrilintide's molecular structure allows for once-weekly administration, making it considerably more practical for research applications
Irg1 is a mitochondrial enzyme that produces itaconates
For the cerebrovascular uptake study ( n = 22), male and female homozygous APOE2-, APOE3-, and APOE4-TR mice were euthanized at 26-weeks (Supplementary Table S2)
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