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The standard protocol from the SUSTAIN trials (Marso et al., New England Journal of Medicine , 2016): Reduce basal insulin dose by 20% on the day you start semaglutide Monitor fasting blood glucose daily for the first 2 weeks Further reduce basal insulin by 10 to 20% if fasting glucose drops below 80 mg/dL or if hypoglycemia occurs Reduce mealtime (bolus) insulin by 20 to 30% during semaglutide titration, adjusting based on post-meal glucose readings Most patients on basal insulin end up reducing total daily insulin dose by 30 to 50% by the time they reach maintenance semaglutide dose
William, A
Front Nutr 12:1566498 Schoenfeld BJ, Aragon AA (2018) How much protein can the body use in a single meal for muscle-building
The medication improves several aspects of health at the same time
It is commonly used as a first choice of treatment
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