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B12 is water-soluble and excess is excreted in urine

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Inhibiting LDHA to reduce lactate synthesis, or developing modulators of p300/HDACs to interfere with the dynamic balance of lactylation has the potential to simultaneously disrupt the metabolic dependency and epigenetic remodeling capabilities of tumors, thereby providing new avenues for combination therapies targeting multiple pathways

This helps ensure safe dosing, early identification of imbalances and timely adjustments to the treatment plan