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Signs of dehydration include decreased urination, dizziness when standing, or extreme thirst

Lilly noted a portion of those were for "perceived excessive weight loss" rather than tolerability patients with lower baseline BMIs were losing weight faster than they wanted

Under stress conditions, LC activity increases and promotes NE release within the hippocampus, whereas prolonged or repeated stress exposure may disrupt LC-NE signaling and result in blunted noradrenergic responsivity (Slavova et al., 2024)