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Discovery of highly potent microsomal prostaglandin E2 synthase 1 inhibitors using the active conformation structural model and virtual screen

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Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

After exposure to H 2 O 2 there was significantly more oxidized Bodipy-C11 in macrophages from healthy donors and individuals with active CD compared to untreated cells indicating increased lipid peroxidation (Fig

Some patients in clinical studies reported improvements within the first treatment cycle (5-20 sessions)