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doi: 10.3389/fnagi.2026.1851072 Received 09 April 2026 Revised 18 May 2026 Accepted 20 May 2026 Published 05 June 2026 Volume 18 - 2026 Edited by Scott E
The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems
Benefits Direct activation of the IGF-1 receptor for anabolic signaling: IGF-1 LR3 binds directly to the IGF-1 receptor expressed on muscle and other peripheral tissues
Oct 2021;86:7-18
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