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FIGURE 2 Upregulating factors Shear stress , the mechanical stimulus exerted on the endothelium by laminar blood flow, upregulates eNOS expression (Nadaud et al., 1996) by triggering PIEZO1 Ca 2+ channels (Wang et al., 2016) and a mechanosensory complex leading to the activation of KLF2 , which binds directly to the NOS3 promoter (Wang et al., 2010

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