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All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)
AOD-9604 Safety: What Do Clinical Trials Show
By inhibiting NNMT activity, 5-Amino-1MQ has been investigated for its potential to alter intracellular nicotinamide metabolism, increase nicotinamide adenine dinucleotide (NAD) availability, and improve mitochondrial energy utilization
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Fatigue and energy changes Some researchers report transient fatigue when first combining the two compounds
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