Other GLP-1 medications remain under patent: Eli Lilly's medications (Mounjaro and Zepbound): Tirzepatide works differently from semaglutide, targeting both GLP-1 and GIP receptors rather than GLP-1 alone
Acts on the brains appetite centers to promote satiety and reduce the urge to overeat
The additional glucagon receptor activation introduces another variable that could influence neurological effects in either direction
Long-acting GLP-1 receptor agonists include: Loxenatide, Exenatide microspheres, Semaglutide, Albiglutide, Dulaglutide, and Efpeglenatide injection, among others
Mitigation strategies include frequent glucose monitoring when changes are made to insulin dosage, oral hypoglycemic medications, meal patterns, physical activity, and in cases of renal or hepatic impairment or hypoglycemia unawareness, with consideration for dose reduction