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The reaction was first described in 1895 by Adolf Jarisch, an Austrian dermatologist, and later in 1902 by Karl Herxheimer, a German dermatologist
Furthermore, excess GSSG is postulated to result in alteration of a variety of cell functions, including enzyme function, protein synthesis, cell integrity, microtubular function, transport processes, and release mechanisms
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The biological plausibility for supplementation rests on restoring something the body already produces and utilizes
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