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The idea that fat mass signals are involved in the hypothalamic control of food intake has already been proposed in 1953 (Figure 1
The most frequently reported side effects include nausea, diarrhea, vomiting, constipation, and abdominal pain
These severe adverse events extend beyond the commonly known nausea or diarrhea
Visca D, Pignatti P, Spanevello A, Lucini E, La Rocca E
Thus, we hypothesized that the elevated non-12-OH FXR-antagonistic BA levels contribute to the glucose-lowering effect of T3 through the regulation of GLP-1 and insulin production via inhibiting intestinal FXR signaling
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