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Safety Considerations and Contraindications GHK-Cu is generally well-tolerated in topical form, but caution is warranted in patients with certain sensitivities or systemic conditions
Additionally, aspartate produced by cancer cells participates in the activation and proliferation of CD8 + T cells
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
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Sadee W, et al
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