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Cryopreservation impacts sperm cellular anatomy and physiology, including changes in sperm characteristics and mRNA downregulation, which are vital for fertilization and early embryo development (95, 113)

Untreated MASLD progresses to metabolic associated steatohepatitis (MASH) in 1520% of cases 2 which can then lead to fibrinogenesis with progression to cirrhosis 3