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A 2019 systematic review of five placebo-controlled trials conducted by one group of investigators examined the effect of acetyl-L-carnitine (ALCAR) in 398 participants with cirrhosis and portal hypertension (high blood pressure in the portal vein) and presenting with either subclinical or overt hepatic encephalopathy
23 In clinical trials, treatment-discontinuation rates are around 5% to 10%
In a separate study that evaluated patient perceptions of the injection devices for liraglutide and dulaglutide, the dulaglutide device was associated with a slightly higher score for ease of use and convenience [128]
Bohm, M., Reil, J
Some patients experience anxiety as a less common but documented side effect, likely related to appetite suppression affecting energy intake and blood sugar patterns
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