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if confirmed, the medication should not be restarted) [1] You develop right-upper abdominal pain, jaundice (yellowing of skin/eyes), pale stools or dark urine (possible gallbladder disease) You develop chest pain, severe breathlessness, or signs of allergic reaction Joint pain follows trauma or injury with suspected fracture Your healthcare provider may undertake investigations including blood tests (inflammatory markers, rheumatoid factor, uric acid), X-rays, or referral to rheumatology if inflammatory arthritis is suspected

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Freezing the medication can ruin its effectiveness, and it should not be used if it has been frozen