We monitored the real-time cell surface dissociation of exendin-4-FITC, exendin-phe1-FITC, and exendin-asp3-FITC in the presence of exendin(9-39), having first inhibited endocytosis using a cocktail of metabolic inhibitors 9 (Fig
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Why It Happens Cagrilintide is a long-acting analogue of amylin, a hormone co-secreted with insulin by the pancreatic beta cells
Therefore, compared to other GLP-1R agonists, exendin-phe1 possesses advantageous pharmacological properties that maximizes insulin secretion