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Any patient who experiences persistent vomiting, severe abdominal pain, or jaundice should be evaluated promptly for pancreatitis or gallbladder disease, both of which occur at modestly elevated rates with GLP-1 class drugs [5]
Other important determinants of vascular aging include genes that are predisposed to lipid and metabolic conditions, epigenetic modifications, psychosocial stress, and environmental exposures to pollutants [77, 79]
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Myostatin is considered to prevent cellular differentiation
Based on these characteristics, the incretin axis continues to be an attractive target for drug development, and GLP-1R agonists (GLP-1RA) have emerged as potent and effective treatments to reduce blood glucose and body weight 7
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