499 A and phosphorylated Tau (p-Tau) neurofibrillary lesions lead to the pathology of neurons that display oxidative damage, impaired Ca2+ processing, reduced DNA repair, dysfunction of lysosomal and mitophagy, all of which have a positive correlation with the age-related NAD + decline
Harmful effects of zinc excess Excess of zinc can have a series of harmful effects on animals, manifested mainly in its interference with the absorption and utilization of other minerals, its impact on enzyme activity, and the potential risk of promoting the emergence of antibiotic-resistant bacteria [150, 154]
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