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Loren Pickart estimated that toxic effects would begin at approximately 22,500 mg, which represents a 300-fold margin above effective therapeutic doses
One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition
doi: 10.4158/EP.5.5.233 25 BiondiB
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Importantly, all anti-TNFs can be continued during lactation [91] and paternal exposure to anti-TNFs during conception period has not been associated with adverse pregnancy outcomes in their partners [93]
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