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Since the excretion of SF and SF metabolites in the urine of human subjects who do not consume cruciferous vegetables or condiments is negligible (less than 0.2 nmol/mL) 24,43 , increases resulting from glucoraphanin with or without the presence of Myr rise well above the baseline concentrations and therefore, a placebo group was not necessary

Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

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