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GLP-1 receptor agonists are shifting healthcare from: glucose control to whole-body metabolic disease modification. The future of endocrinology will likely be built around: precision metabolic medicine, multi-agonist therapies, oral incretin platforms, and integrated cardiometabolic care
Immunofluorescent staining of human testes revealed that FOXO4 expression was primarily localized to the interstitial or peritubular cells, but not within the seminiferous tubules
The authors explicitly note that these AE/SAE rates are broadly comparable to pivotal programs for weekly semaglutide (high overall AE rates, ~10% SAE) and tirzepatide (~80% AE rates, ~57% SAE), and they argue tolerability can be further improved with a more conservative titration scheme in Phase 3
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