Klein An in-depth look into what the drug is being used for and what has contributed to the shortage
While semaglutide has emerged as a revolutionary treatment for obesity and type 2 diabetes, offering significant benefits in weight loss and glycemic control, it is not without its side effects
In recent works, the study demonstrated that GCH1/ BH4 pathic enzyme dihydrofolate reductase (DHFR) could inhibit ferroptosis by generating BH4, so decrease in DHFR activity reduces BH4 content to enhance lipid peroxidation and sensitizes cells to ferroptosis (Lu et al., 2024), but the detail process is still unknown (Figure 1)
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Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis