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By designing a molecule that favors the GIPR, Tirzepatide can be dosed to achieve full engagement of the GIP pathway's metabolic benefits, while the less potent but still effective GLP-1R agonism provides its complementary effects without reaching the same tolerability ceiling that might limit a selective GLP-1 RA
Ipamorelin is a type of peptide called a growth hormone secretagogue
Kim et al., 2016
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The GLP-1 micro dosing often corrects this
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