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Understanding Insulin-like Growth Factor-1 Insulin-like growth factor-1 (IGF-1), formerly known as somatomedin or somatomedin C, has a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges. Although IGF-1 provides several benefits similar to insulin such as lower blood sugar levels, the key difference is that insulin mediates mainly a metabolic response, whereas IGF-1 mediates growth-promoting effects (Source)