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Reconstituting with larger solvent volumes (45mL) improves measurement precision for low doses but depletes the vial faster across multiple injections
A cross-sectional and longitudinal study using LC-MS and non-targeted metabolomics reported that citrulline showed lower relative concentrations in individuals with metformin-treated T2D individuals compared to those without metformin treatment in the human study
References Griffiths, C
Enns, GM, Moore, T, Le, A, Atkuri, K, Shah, MK, Cusmano-Ozog, K, Niemi, AK, Cowan, TM 2014, Degree of Glutathione Deficiency and Redox Imbalance Depend on Subtype of Mitochondrial Disease and Clinical Status, The Public Library of Science One , vol
