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Improved Mobility : Weight loss enhances mobility and flexibility, making it easier for individuals to engage in physical activities
GLP-1 receptor agonists help counteract these problems by improving insulin sensitivity and reducing hepatic glucose production, thereby promoting weight loss
At the 12mg dose in TRIUMPH-1: Average weight loss of 28.3% at 80 weeks within the range of bariatric surgery outcomes 45.3% of participants lost 30% or more the threshold associated with bariatric surgery in published literature 65.3% achieved BMI below 30 no longer classifiable as obese by standard criteria Extension data to 104 weeks shows 30.3% average continuing to approach surgical outcomes with longer treatment The comparison is not a simple equivalence
[1] [2] It belongs to a novel class of medications known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists
Many healthcare providers recommend pausing or carefully reassessing semaglutide use during this time , as further slowing digestion may worsen discomfort or delay recovery
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