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Step 2: 5, 10-methylenetetrahydrofolate is converted into methylfolate (5-MTHF) by the enzyme methylenetetrahydrafolate reductase (MTHFR) with the aid of NADH, B2 and ATP

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Stacking multiple GLP-1 agonists together, such as semaglutide and tirzepatide, is generally not recommended due to overlapping mechanisms and increased side effect risk