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The brain stem and cerebellum were removed, and the two remaining hemispheres were homogenized with 1.5 ml ice-cold trichloroacetic acid (50% v/v) in a glass homogenizer

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IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is an 83-amino-acid synthetic variant of human IGF-1, engineered with two key structural modifications: a glutamic acid substitution for arginine at position 3 (R3) and a 13-amino-acid N-terminal extension peptide

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Cancer cell senescence is primarily caused by oncogene-induced senescence (OIS) or therapy-induced senescence (TIS)

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