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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

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There is an optimal working point on this, which may only move slightly along the working curve

The reciprocal experiment to specifically cleave K29 linkages was technically challenging at this stage because K29/K33-linkage-specific TRABID can also cleave other linkages such as K63 linkage in vitro 34