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Figure 4 Effects on Polycystic Ovary Syndrome Polycystic ovary syndrome (PCOS), which is mainly manifested as sparse ovulation or non-ovulation, high levels of androgens, ovarian polycystic changes, obesity, and infertility, is the most common endocrine and metabolic disorder in women of childbearing age (139)

By blasting all three targets, retatrutide not only suppresses appetite and stimulates insulin, but may increase fat burning

Key Expert Opinions Sean Wharton, lead study author and medical director of the Wharton Medical Clinic, Canada, emphasized the clinical significance of the findings, stating that The STEP UP trial demonstrated that we can increase the dose of semaglutide and achieve greater weight loss than previously seen, and in line with semaglutide established safety profile

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