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[10] These studies should be described as preclinical cytoprotection research, not as evidence for human gastrointestinal treatment
[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses
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Discontinuation because of adverse events remained low at 5.9%
Safety data in humans is not as robust as it is for FDA approved medications
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