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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
Fatigue or Dizziness Some individuals report temporary fatigue, lightheadedness, or low energy early during treatment
More acidic or alkaline conditions may affect peptide stability or cause irritation
The panel makes its recommendations to the FDA, which will then determine whether to begin the process of approving these peptides
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