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In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

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The result of the trial- no changes were observed in the fertility of males

Health Canada Review Status Health Canada is currently reviewing nine applications for generic semaglutide from various manufacturers, with some applications filed as early as February 2024