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This increase in lysine content is attributed to an opaque-2 mutation that reduced the transcription of lysine-lacking zein-related seed storage proteins and, as a result, increased the abundance of other proteins that are rich in lysine

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Following the readout of REDEFINE 1 in late 2024 which fell short of expectations, positive REDEFINE 4 data will become even more important for CagriSema, however, its outcome is now less certain

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