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Keaney, Jr., M.D

In contrast, increased cell death was consistently observed across various lymphoid cell types, including tumor cells, underscoring that, within 3D gels, cell death, rather than cell cycle arrest, impedes lymphoid cell growth

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AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M